VCFArrow - Fast and Memory-Efficient Manipulation and Conversion of VCF Files

Reads Variant Call Format (VCF) files into an S4 object whose genotypes are stored on disk as an 'Apache Arrow' dataset and loaded lazily, allowing large datasets to be processed with little memory. Provides functions to filter variants and samples, subset and merge datasets, compute summary statistics and diagnostic plots, write VCF files, and convert data to input formats of population genetic and phylogenetic software such as 'STRUCTURE', 'ADMIXTURE', 'PLINK', 'EIGENSTRAT', 'Arlequin', 'GENEPOP', 'BayeScan', 'TreeMix', 'SNAPP' and 'adegenet'.